Stability of glycosylated complexes loaded with Epigallocatechin 3-gallate (EGCG)

文献类型： 外文期刊

第一作者： Zhang, Jianyong

作者： Zhang, Jianyong;Qiu, Jiahuan;Wang, Xiaoqing;Zhong, Yixin;Yao, Caiping;Yao, Lanying;Zheng, Qunxiong;Xiong, ChunHua;Zhang, Jianyong;Cui, Hongchun

作者机构：

关键词： EGCG; Arachin; Casein; Glycosylation; Antioxidation; Stability

期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）

ISSN： 0308-8146

年卷期： 2023 年 410 卷

页码：

收录情况： SCI

摘要： The application of Epigallocatechin-3-gallate (EGCG) in food industry was limited by its low stability in aqueous solutions and poor bioavailability in vivo. The novel EGCG glycosylated arachin nanoparticles (Ara-CMCS-EGCG) and EGCG glycosylated casein nanoparticles (Cas-CMCS-EGCG) were prepared to improve the stability and bioavailability of EGCG. The effect of different variables on the storage stability and the slow-release behavior of novel glycosylation complexes in nanoparticle background solution and artificial gastrointestinal fluid were investigated. The results showed that the DPPH center dot scavenging activity of Ara-CMCS-EGCG and Cas-CMCS-EGCG were stable in temperature (25 similar to 70 degrees C). EGCG could enhance the crosslinking effect of molecular particles in glycosylation complexes solution. The glycosylated protein nanoparticles were stable to acid-base and enzymolysis in simulated gastrointestinal fluid. The release rate of EGCG in simulated intestinal fluid was higher than that in simulated gastric fluid. The glycosylated protein carrier can not only release EGCG slowly, but also significantly improve the stability and bioavailability of EGCG in simulated gastrointestinal fluid.

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