A phase-separated protein hub modulates resistance to Fusarium head blight in wheat

文献类型： 外文期刊

第一作者： He, Yi

作者： He, Yi;Wang, Yuhua;Dong, Yifan;Zhang, Zhengguang;Li, Gang;He, Yi;Wu, Lei;Jiang, Peng;Zhang, Xu;Yang, Xiujuan;Tucker, Matthew R.;Xia, Xiaobo;Jiang, Cong;Ma, Hongxiang;Ma, Wujun;Liu, Cong;Whitford, Ryan

作者机构： Nanjing Agr Univ, Coll Plant Protect, Dept Plant Pathol, Nanjing 210095, Peoples R China;Jiangsu Acad Sci, Key Lab Germplasm Innovat Downstream Huaihe River, Minist Agr & Rural Affairs, CIMMYT JAAS Joint Ctr Wheat Dis,Res Ctr Wheat Scab, Nanjing 210014, Peoples R China;Univ Adelaide, Waite Res Inst, Sch Agr Food & Wine, Urrbrae, SA 5064, Australia;Northwest A&F Univ, Coll Plant Protect, Yangling 712100, Peoples R China;Yangzhou Univ, Coll Agr, Yangzhou 225009, Peoples R China;Qingdao Agr Univ, Coll Agron, Qingdao 266000, Peoples R China;Chinese Acad Sci, Interdisciplinary Res Ctr Biol & Chem, Shanghai Inst Organ Chem, Shanghai 201210, Peoples R China;Murdoch Univ, Food Futures Inst, Ctr Crop & Food Innovat CCFI, State Agr Biotechnol Ctr SABC, Murdoch, WA 6150, Australia

期刊名称：CELL HOST & MICROBE （ 2023影响因子：20.6； 五年影响因子：22.1 ）

ISSN： 1931-3128

年卷期： 2024 年 32 卷 5 期

页码：

收录情况： SCI

摘要： Fusarium head blight (FHB) is a devastating wheat disease. Fhb1 , the most widely applied genetic locus for FHB resistance, is conferred by TaHRC of an unknown mode of action. Here, we show that TaHRC alleles distinctly drive liquid -liquid phase separation (LLPS) within a proteinaceous complex, determining FHB susceptibility or resistance. TaHRC-S (susceptible) exhibits stronger LLPS ability than TaHRC-R (resistant), and this distinction is further intensified by fungal mycotoxin deoxynivalenol, leading to opposing FHB symptoms. TaHRC recruits a protein class with intrinsic LLPS potentials, referred to as an "HRC-containing hub."TaHRC-S drives condensation of hub components, while TaHRC-R comparatively suppresses hub condensate formation. The function of TaSR45a splicing factor, a hub member, depends on TaHRC-driven condensate state, which in turn differentially directs alternative splicing, switching between susceptibility and resistance to wheat FHB. These findings reveal a mechanism for FHB spread within a spike and shed light on the roles of complex condensates in controlling plant disease.

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