Molecular characterization and functional analysis of TRIM37 from black tiger shrimp (Penaeus monodon)

文献类型： 外文期刊

第一作者： Zhao, Chao

作者： Zhao, Chao;Peng, Chao;Wang, Pengfei;Zhang, Bo;Yan, Lulu;Qiu, Lihua;Zhao, Chao;Wang, Chun-Lin

作者机构：

关键词： Penaeus monodon; PmTRIM37; WSSV; Innate immunity; AMP

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.7； 五年影响因子：4.7 ）

ISSN： 1050-4648

年卷期： 2023 年 140 卷

页码：

收录情况： SCI

摘要： The family of TRIM proteins with E3 ubiquitin ligase activity served important roles in the regulation of innate immune processes, in particular antiviral and proinflammatory cytokine responses. In this study, a novel TRIM37 homolog was identified from Penaeus monodon (named PmTRIM37). The PmTRIM37 protein contained three conserved domains (one RING finger domain, a B-box, and one Coiled-coil region) at its N-terminal and one Meprin and MATH domain at its C-terminal. The MATH domain was the characteristic of TRIM37 family. PmTRIM37 has relatively high expression in immune-related tissues such as hepatopancreas, gills, lymphoid organs and hemocytes. The expression levels of PmTRIM37 in hepatopancreas and lymphoid organs were significantly up-regulated after white spot syndrome virus (WSSV) infection. Knock down of PmTRIM37 pro-moted WSSV replication and VP28 expression, suggesting that PmTRIM37 played a negative role in WSSV infection. Further studies revealed that PmTRIM37 positively regulated the NF-& kappa;B pathway and Antimicrobial peptides (AMP) expression during WSSV infection. These findings indicated that PmTRIM37 might restrict WSSV replication by positively regulating NF-& kappa;B pathway during WSSV infection in P. monodon.

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