文献类型： 外文期刊
第一作者： Wang, Tong-Yun
作者： Wang, Tong-Yun;Sun, Ming-Xia;Zhang, Hong-Liang;Wang, Gang;Tian, Zhi-Jun;Cai, Xue-Hui;Tang, Yan-Dong;Zhan, Guoqing;Su, Chenhe;Zhan, Guoqing
作者机构：
关键词： antiviral innate immunity; PRRSV; PRRs; interferon; JAK-STAT; immune evasion; ISGs
期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.64； 五年影响因子：6.32 ）
ISSN：
年卷期： 2021 年 12 卷
页码：
收录情况： SCI
摘要： Innate immunity is the front line for antiviral immune responses and bridges adaptive immunity against viral infections. However, various viruses have evolved many strategies to evade host innate immunity. A typical virus is the porcine reproductive and respiratory syndrome virus (PRRSV), one of the most globally devastating viruses threatening the swine industry worldwide. PRRSV engages several strategies to evade the porcine innate immune responses. This review focus on the underlying mechanisms employed by PRRSV to evade pattern recognition receptors signaling pathways, type I interferon (IFN-alpha/beta) receptor (IFNAR)-JAK-STAT signaling pathway, and interferon-stimulated genes. Deciphering the antiviral immune evasion mechanisms by PRRSV will enhance our understanding of PRRSV's pathogenesis and help us to develop more effective methods to control and eliminate PRRSV.
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