Copper and Zinc Treatments Alter the Thyroid Endocrine System in Zebrafish Embryos/Larvae

文献类型： 外文期刊

第一作者： Zhong, Liqiao

作者： Zhong, Liqiao;Wu, Luyin;Ru, Huijun;Wei, Nian;Yao, Fan;Ni, Zhaohui;Duan, Xinbin;Li, Yunfeng;Zhang, He;Zhang, He

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关键词： copper and zinc; hypothalamus-pituitary-thyroid axis; thyroid disruption; zebrafish

期刊名称：TOXICS （ 影响因子：4.472； 五年影响因子：5.144 ）

ISSN：

年卷期： 2022 年 10 卷 12 期

页码：

收录情况： SCI

摘要： Copper (Cu2+) and zinc (Zn2+) are two kinds of heavy metals essential to living organisms. Cu2+ and Zn2+ at excessive concentrations can cause adverse effects on animals, but little is known about the thyroid-disrupting effects of these metals in fish, especially in the early developmental transition stage from embryos to larvae. Wild-type zebrafish embryos were used to expose to Cu2+ (0, 1.5, 15, and 150 mu g/L) and Zn2+ (0, 20, 200, and 2000 mu g/L) for 120 h. Thyroid hormone contents and transcriptional changes of the genes connected with the hypothalamic-pituitary-thyroid (HPT) axis were measured. Results showed that zebrafish embryos/larvae malformation rates were significantly increased in the Cu2+ and Zn2+ groups. Remarkably elevated thyroxine (T4) concentrations and reduced triiodothyronine (T3) concentrations were observed in Cu2+ and Zn2+ exposure fish. And the expression patterns of genes connected with the HPT axis were changed after Cu2+ and Zn2+ treatment. Based on principal component analysis (PCA) results, Zn2+ caused significant effects on the thyroid endocrine system at 200 mu g/L, while Cu2+ resulted in thyroid disruption as low as 1.5 mu g/L. In short, our study demonstrated that exposure to Cu2+ and Zn2+ induced developmental toxicity and thyroid disruption to zebrafish embryos/larvae.

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