Research note: Unveiling the impact of ovotransferrin on chicken primordial germ cells biological processes

文献类型： 外文期刊

第一作者： Liu, Xin

作者： Liu, Xin;Peng, Yixiu;Wu, Jun;Qian, Hongwu;Lv, Xiaoqian;Li, Fan;Jin, Kai;Niu, Yingjie;Chen, Guohong;Li, Bichun;Zuo, Qisheng;Liu, Xin;Peng, Yixiu;Wu, Jun;Qian, Hongwu;Lv, Xiaoqian;Li, Fan;Jin, Kai;Niu, Yingjie;Chen, Guohong;Li, Bichun;Zuo, Qisheng;Liu, Xin;Peng, Yixiu;Wu, Jun;Qian, Hongwu;Lv, Xiaoqian;Li, Fan;Jin, Kai;Niu, Yingjie;Chen, Guohong;Li, Bichun;Zuo, Qisheng;Song, Jiuzhou;Han, Wei;Li, Bichun

作者机构：

关键词： Chicken; Primordial germ cell; ovotransferrin; chicken; serum

期刊名称：POULTRY SCIENCE （ 影响因子：4.2； 五年影响因子：4.5 ）

ISSN： 0032-5791

年卷期： 2025 年 104 卷 7 期

页码：

收录情况： SCI

摘要： In the field of genetic breeding, primordial germ cells (PGCs) have become essential cells for gene editing and genetic improvement due to their unique developmental potential and genetic characteristics. However, the low proliferation efficiency and instability of culture systems pose significant challenges, severely limiting the application of PGCs in genetic breeding. In this study, the biological effects of ovotransferrin on chicken PGCs, focusing on its role in regulating key cellular processes. Treatment with 0.5 mg/ml ovotransferrin significantly promoted cell proliferation, enhanced cell adhesion, reduced oxidative stress, and suppressed apoptosis in cultured PGCs. These findings reveal a regulatory role of ovotransferrin in maintaining PGCs survival and function, providing new insights into optimizing PGC culture systems through targeted modulation of cell fate.

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