Immune escape of avian oncogenic Marek's disease herpesvirus and antagonistic host immune responses

文献类型： 外文期刊

第一作者： Zhu, Zhi-Jian

作者： Zhu, Zhi-Jian;Liu, Yu;Chen, Fu-Jia;Li, En-Zhong;Zhu, Zhi-Jian;Liu, Yu;Chen, Fu-Jia;Li, En-Zhong;Zhu, Zhi-Jian;Teng, Man;Luo, Jun;Zhu, Zhi-Jian;Teng, Man;Luo, Jun;Zhu, Zhi-Jian;Teng, Man;Luo, Jun;Zhu, Zhi-Jian;Teng, Man;Luo, Jun;Yao, Yongxiu;Yao, Yongxiu;Luo, Jun;Luo, Jun

作者机构：

期刊名称：NPJ VACCINES （ 影响因子：6.9； 五年影响因子：6.7 ）

ISSN：

年卷期： 2024 年 9 卷 1 期

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收录情况： SCI

摘要： Marek's disease virus (MDV) is a highly pathogenic and oncogenic alpha herpesvirus that causes Marek's disease (MD), which is one of the most important immunosuppressive and rapid-onset neoplastic diseases in poultry. The onset of MD lymphomas and other clinical diseases can be efficiently prevented by vaccination; these vaccines are heralded as the first demonstration of a successful vaccination strategy against a cancer. However, the persistent evolution of epidemic MDV strains towards greater virulence has recently resulted in frequent outbreaks of MD in vaccinated chicken flocks worldwide. Herein, we provide an overall review focusing on the discovery and identification of the strategies by which MDV evades host immunity and attacks the immune system. We have also highlighted the decrease in the immune efficacy of current MD vaccines. The prospects, strategies and new techniques for the development of efficient MD vaccines, together with the possibilities of antiviral therapy in MD, are also discussed.

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