Novel H7N7 avian influenza viruses detected in migratory wild birds in eastern China between 2018 and 2020

文献类型： 外文期刊

第一作者： Zhao, Conghui

作者： Zhao, Conghui;Zeng, Xianying;Shi, Jianzhong;Deng, Guohua;Zhang, Yaping;Ma, Qi;Cui, Pengfei;Liu, Liling;Chen, Hualan;Guo, Jing;Wang, Yanwen;Gao, Xinxin;Li, Xuyong

作者机构：

关键词： Avian influenza virus; H7N7; Wild birds; Genetic; Replication

期刊名称：MICROBES AND INFECTION （ 影响因子：9.57； 五年影响因子：5.561 ）

ISSN： 1286-4579

年卷期： 2022 年 24 卷 8 期

页码：

收录情况： SCI

摘要： Wild birds are the natural reservoirs of avian influenza viruses, and surveillance and assessment of these viruses in wild birds provide valuable information for early warning and control of animal diseases. In this study, we isolated 19 H7N7 avian influenza viruses from wild bird between 2018 and 2020. Full genomic analysis revealed that these viruses bear a single basic amino acid in the cleavage site of their hemagglutinin gene, and formed four different genotypes by actively reassorting other avian influenza viruses circulating in wild birds and ducks. The H7N7 viruses bound to both avian-type and human-type receptors, although their affinity for human-type receptors was markedly lower than that for avian-type receptors. Moreover, we found that the H7N7 viruses could replicate efficiently in the upper respiratory tract and caecum of domestic ducks, and that the H5/H7 inactivated vaccine used in poultry in China provided complete protection against H7N7 wild bird virus challenge in ducks. Our findings demonstrate that wild bird H7N7 viruses pose a substantial threat to the poultry industry across the East Asian -Australian migratory flyway, emphasize the importance of influenza virus surveillance in both wild and domestic birds, and support the development of active control strategies against H7N7 virus. (C) 2022 Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences. Published by Elsevier Masson SAS on behalf of Institut Pasteur.

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