Curcumin Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice Through Regulating Gut Microbiota

文献类型： 外文期刊

第一作者： Guo, Xiaoxuan

作者： Guo, Xiaoxuan;Qiu, Jing;Xu, Ye;Geng, Ruixuan;He, Xiaoyun

作者机构：

关键词： curcumin; colitis; gut barrier; inflammation; apoptosis; gut microbiota

期刊名称：MOLECULAR NUTRITION & FOOD RESEARCH （ 影响因子：6.575； 五年影响因子：6.883 ）

ISSN： 1613-4125

年卷期： 2022 年 66 卷 8 期

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收录情况： SCI

摘要： Scope Curcumin is a natural polyphenol compound with multiple pharmacologic activities. The present study aims to explore the potential therapeutic properties of curcumin on intestinal inflammatory diseases, including its anti-inflammatory, antioxidant, and anti-apoptotic properties, as well as their associations with altered intestinal microbiome. Methods and Results DSS, i.e., Dextran Sulfate Sodium, (3%) is administered to C57BL/6J mice in the drinking water daily for 6 days in DSS and curcumin groups. Then, mice in curcumin groups are orally administered with 50 or 150 mg kg(-1) curcumin for 7 days. On day 13, mice are sacrificed. Results show that oral administration with curcumin relieves macroscopic pathological manifestations, e.g., colon length and histological change. Moreover, it enhances intestinal barrier via increasing expression of tight junction proteins, e.g., occludin, ZO-1, claudin-3; alleviates DSS-induced intestinal apoptosis via suppressing caspase-3 pathway; mitigates intestinal inflammation via inhibiting the MAPK/NF kappa B/STAT3 pathway. It is also noticed that curcumin is beneficial for modulating abundance of some specific bacteria, including Akkermansia, Coprococcus, Roseburia, and Turicibacter, as well as families such as F16, Enterococcaceae, and Aerococcaceae. Most of the altered bacteria by curcumin are highly correlated with colitis-associated parameters. Conclusion Curcumin shows therapeutic potential against colitis. It may be served as an alternative medicine or adjuvant therapy in the treatment of colitis.

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