Sciadonic acid ameliorates cyclophosphamide-induced immunosuppression by modulating the immune response and altering the gut microbiota

文献类型： 外文期刊

第一作者： Chen, Lin

作者： Chen, Lin;Jiang, Qihong;Jiang, Chenkai;Lu, Hongling;Hu, Wenjun;Yu, Shaofang;Shen, Guoxin;Yao, Shiwei;Xiang, Xingwei;Li, Mingqian;Feng, Yongcai;Tan, Chin Ping

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关键词： cyclophosphamide; gut microbiota; immunomodulatory activity; intestinal barrier; sciadonic acid

期刊名称：JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE （ 影响因子：4.1； 五年影响因子：4.2 ）

ISSN： 0022-5142

年卷期： 2024 年 104 卷 7 期

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收录情况： SCI

摘要： BACKGROUNDCyclophosphamide (Cy) is a frequently used chemotherapeutic drug, but long-term Cy treatment can cause immunosuppression and intestinal mucosal damage. The intestinal mucosal barrier and gut flora play important roles in regulating host metabolism, maintaining physiological functions and protecting immune homeostasis. Dysbiosis of the intestinal flora affects the development of the intestinal microenvironment, as well as the development of various external systemic diseases and metabolic syndrome.RESULTSThe present study investigated the influence of sciadonic acid (SA) on Cy-induced immunosuppression in mice. The results showed that SA gavage significantly alleviated Cy-induced immune damage by improving the immune system organ index, immune response and oxidative stress. Moreover, SA restored intestinal morphology, improved villus integrity and activated the nuclear factor kappa B signaling pathway, stimulated cytokine production, and reduced serum lipopolysaccharide (LPS) levels. Furthermore, gut microbiota analysis indicated that SA increased t beneficial bacteria (Alistipes, Lachnospiraceae_NK4A136_group, Rikenella and Odoribacter) and decreased pathogenic bacteria (norank-f-Oscillospiraceae, Ruminococcus and Desulfovibrio) to maintain intestinal homeostasis.CONCLUSIONThe present study provided new insights into the SA regulation of intestinal flora to enhance immune responses. (c) 2024 Society of Chemical Industry.

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