Enhancing Growth and Intestinal Health in Triploid Rainbow Trout Fed a Low-Fish-Meal Diet through Supplementation with Clostridium butyricum

文献类型： 外文期刊

第一作者： Wang, Chang'an

作者： Wang, Chang'an;Li, Fangyuan;Wang, Di;Lu, Shaoxia;Han, Shicheng;Gu, Wei;Liu, Hongbai;Wang, Chang'an;Jiang, Haibo;Li, Zhuang

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关键词： triploid rainbow trout; C. butyricum; low-fish-meal diet; growth performance; intestinal health

期刊名称：FISHES （ 影响因子：2.3； 五年影响因子：2.4 ）

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年卷期： 2024 年 9 卷 5 期

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收录情况： SCI

摘要： This study evaluates the effects of dietary Clostridium butyricum on growth performance and intestinal health in triploid rainbow trout (Oncorhynchus mykiss). Administered in a 12-week trial, five isonitrogenous and isolipidic feeds contained different C. butyricum levels [G1 (0), G2 (1.6 x 10(6) CFU/g), G3 (1.2 x 10(7) CFU/g), G4 (1.1 x 10(8) CFU/g), and G5 (1.3 x 10(9) CFU/g)]. Significant enhancements in growth performance, including improved feed conversion ratios and specific growth rates in the G4 group, were indicative of enhanced nutrient utilization, corroborated by optimal digestive enzyme activity levels. Antioxidant capabilities were also enhanced in the G4 group, indicated by increased serum superoxide dismutase and catalase activities, along with a significant decrease in malondialdehyde levels. Gut microbiota analysis indicated a probiotic concentration-dependent modulation of microbial communities, with a marked enrichment in beneficial bacterial phyla like Firmicutes in the G4 group. This microbial shift correlated with significant downregulations in immune-related gene expressions, including interleukins (IL-1 beta, IL-8), NF-kappa B, MyD88, and TNF-alpha, highlighting an activated immune response. Correspondingly, serum lysozyme and immunoglobulin M contents were significantly elevated in the G4 group. Challenge tests with Aeromonas salmonicida exhibited the higher disease resistance of fish fed the G4 diet. In conclusion, the study shows the potential of dietary C. butyricum, especially at 1.1 x 10(8) CFU/g, in enhancing the growth, health, and disease resistance of triploid rainbow trout through modulating gut microflora and stimulating immune responses.

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