Comparative Metabolomics Analysis of Juvenile Takifugu obscurus serum and Liver Samples after Exposure to Tributyltin Chloride

文献类型： 外文期刊

第一作者： Xu, Dong-Po

作者： Xu, Dong-Po;Fang, Di-An;Zhao, Chang-Sheng;Xu, Dong-Po;Fang, Di-An;Jiang, Shu-Lun

作者机构：

关键词： Takifugu obscures; TBT-Cl exposure; metabolic pathway

期刊名称：POLISH JOURNAL OF ENVIRONMENTAL STUDIES （ 影响因子：1.699； 五年影响因子：1.654 ）

ISSN： 1230-1485

年卷期： 2021 年 30 卷 4 期

页码：

收录情况： SCI

摘要： Tributyltin chloride (TBT-Cl), one of the most representative chemical compounds of tributyltin (TBT), is a threat to aquatic organisms due to evidence of fatal toxicity, which has attracted much interest in the scientific community. We studied the effects of acute TBT-Cl exposure on the juvenile Takifugu obscurus metabolism by investigating the metabolite contents in the serum and liver at three TBT-Cl concentrations and in a control group using the LC-MS technology. The metabolites that showed different levels in the serum and liver under different TBT-C1 concentrations were primarily related to sphingolipid metabolism, phosphoglyceride metabolism, and the biosynthesis of unsaturated fatty acids. Moreover, we found that TBT-Cl exposure increased the concentration of lysophosphatidylcholine and prostaglandin E-2, resulting in higher detoxification capacity and inhibiting inflammation. These results may explain the higher tolerance of juvenile T. obscurus to TBT-Cl compared with other fish species. Overall, the present study contributes new information of the influences of TBT-Cl on juvenile T. obscurus metabolism.

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