The poultry pathogen Riemerella anatipestifer appears as a reservoir for Tet(X) tigecycline resistance

文献类型： 外文期刊

第一作者： Umar, Zeeshan

作者： Umar, Zeeshan;Chen, Qiwei;Tang, Biao;Xu, Yongchang;Zhang, Huimin;Ji, Kai;Feng, Youjun;Umar, Zeeshan;Chen, Qiwei;Tang, Biao;Xu, Yongchang;Zhang, Huimin;Ji, Kai;Feng, Youjun;Umar, Zeeshan;Xu, Yongchang;Feng, Youjun;Chen, Qiwei;Tang, Biao;Tang, Biao;Wang, Jinzi;Wang, Jinzi;Zhang, Huimin;Jia, Xu;Feng, Youjun

作者机构：

期刊名称：ENVIRONMENTAL MICROBIOLOGY （ 影响因子：5.491； 五年影响因子：6.438 ）

ISSN： 1462-2912

年卷期：

页码：

收录情况： SCI

摘要： The transferability of bacterial resistance to tigecycline, the 'last-resort' antibiotic, is an emerging challenge of global health concern. The plasmid-borne tet(X) that encodes a flavin-dependent monooxygenase represents a new mechanism for tigecycline resistance. Natural source for an ongoing family of Tet(X) resistance determinants is poorly understood. Here, we report the discovery of 26 new variants [tet(X18) to tet(X44)] from the poultry pathogen Riemerella anatipestifer, which expands extensively the current Tet(X) family. R. anatipestifer appears as a natural reservoir for tet(X), of which the chromosome harbours varied copies of tet(X) progenitors. Despite that an inactive ancestor rarely occurs, the action and mechanism of Tet(X2/4)-P, a putative Tet(X) progenitor, was comprehensively characterized, giving an intermediate level of tigecycline resistance. The potential pattern of Tet(X) dissemination from ducks to other animals and humans was raised, in the viewpoint of ecological niches. Therefore, this finding defines a large pool of natural sources for Tet(X) tigecycline resistance, heightening the need of efficient approaches to manage the inter-species transmission of tet(X) resistance determinants.

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