Analysis of Multiclass Pesticide Residues in Tobacco by Gas Chromatography Quadrupole Time-of-Flight Mass Spectrometry Combined with Mini Solid-Phase Extraction

文献类型： 外文期刊

第一作者： Bie, Rui

作者： Bie, Rui;Zhang, Jiguang;Wang, Yunbai;Cao, Jianmin;Jin, Dongmei;Yin, Rui;Jiang, Bin

作者机构：

关键词： mini solid-phase extraction; multiclass pesticide residues; tobacco; gas chromatography quadrupole time-of-flight mass spectrometry

期刊名称：SEPARATIONS （ 影响因子：3.344； 五年影响因子：2.943 ）

ISSN：

年卷期： 2022 年 9 卷 5 期

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收录情况： SCI

摘要： A screening method using gas chromatography quadrupole time-of-flight mass spectrometry (GC-QTOF/MS) combined with mini solid-phase extraction (mini-SPE) was established for the quantification and validation of multiclass pesticide residues in tobacco. The method was quicker and easier, with sample purity higher than that obtained by traditional SPE and dispersed-SPE. Box-Behnken design, an experimental design for response-surface methodology, was used to optimize the variables affecting the target pesticide recovery. Under the optimized conditions, 92% of the pesticides showed satisfactory recoveries of 70%-120% with precision <20% at spiking levels of 50, 250, and 500 ng/g. The limits of detection and quantification for all the analyses were 0.05-29.9 ng/g and 0.20-98.8 ng/g, respectively. In addition, a screening method based on the retention time and a homebuilt high-resolution mass spectrometry database were established. Under the proposed screening parameters and at spiking levels of 50, 100, and 500 ng/g, 76.6%, 94.7%, and 99.0% multiclass pesticide residues were detected, respectively, using the workflow software. The validated method was successfully applied to the analysis of real tobacco samples. Thus, the combination of mini-SPE and GC-QTOF/MS serves as a suitable method for the quantitative analysis and rapid screening of multiclass pesticide residues in tobacco.

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