文献类型： 外文期刊
第一作者： Liang, Ruiying
作者： Liang, Ruiying;Liang, Lin;Zhao, Jingjie;Cui, Shangjin;Zhang, Xinglin;Zhang, Lingling;Liu, Weiquan
作者机构：
关键词： FPV; MiR-92a-1-5p; SP1; SOCS5; Type I interferons
期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.3； 五年影响因子：3.5 ）
ISSN： 0378-1135
年卷期： 2022 年 273 卷
页码：
收录情况： SCI
摘要： MicroRNAs (miRNAs) are vital post-transcriptional regulators that participate in host-pathogen interactions by modulating the expression of cellular factors. Previous studies have demonstrated that feline panleukopenia virus (FPV) alters miRNA expression levels within host cells. However, the relationship between FPV replication and host miRNAs remains unclear. Here, we demonstrated that FPV infection significantly altered cellular miR-92a1-5p expression in F81 cells by upregulating the expression of specificity protein 1 (SP1). Furthermore, we observed that miR-92a-1-5p enhanced interferon (IFN-alpha/ss) expression by targeting the suppressors of cytokine signaling 5 (SOCS5) that negatively regulates NF-.B signaling and inhibits FPV replication in host cells. These findings revealed that miR-92a-1-5p plays a crucial role in host defense against FPV infection.
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