Female zebrafish ( Danio rerio) ) exposure to polystyrene nanoplastics induces reproductive toxicity in mother and their offspring

文献类型： 外文期刊

第一作者： Zhang, Chunyun

作者： Zhang, Chunyun;Yan, Zebang;Wang, Lixin;Xiong, Dongmei;Li, Luoxin;Alava, Juan Jose;Chen, Peng;Gul, Yasmeen

作者机构：

关键词： PS-NPs; Maternal exposure; Reproductive dysfunction; Zebrafish

期刊名称：AQUATIC TOXICOLOGY （ 影响因子：4.1； 五年影响因子：4.4 ）

ISSN： 0166-445X

年卷期： 2024 年 273 卷

页码：

收录情况： SCI

摘要： Nanoplastics (NPs) have been commonly detected in aquatic ecosystems, and their negative effects on aquatic organisms have raised concerns in the scientific community and general public. The acute toxicity, neurotoxicity, and metabolic toxicity induced by NPs on fishes have been reported by many studies, although less attention has been focused on how mother exposed to NPs affected their offspring in aquatic organisms. Here, female zebrafish (F0) were exposed to 0, 200 and 2000 mu g/L polystyrene nanoplastics (PS-NPs) for 42 d, with their offspring (F1) reared in clear water until sexual maturity. The results showed that PS-NPs were detected in various organs of F0 and F1. PS-NPs exposure significantly decreased gonadal 17-estradiol (E2), while increasing testosterone (T) contents. Lower levels of cyp19a1a, lhr and er alpha expressions in the 2000 mu g/L group were consistent with a reduced number of mature oocytes (MO), but an increase in perinucleolar oocytes (PO). Interestingly, the expression of vtg was only up-regulated by 200 mu g/L PS-NPs. After exposure, the egg production was dramatically reduced, but the hatching rate and heartbeat of F1 embryos from treated females were significantly higher than those observed in females from the control group. Maternal PS-NPs exposure significantly decreased the E2 and T levels in F1 adults, while PS-NPs exposure significantly up-regulated the sox9a but down-regulated the foxl2a in F1 larvae of 30 days post fertilization (dpf). This study showed that PS-NPs caused reproductive toxicity by changing the hypothalamic-pituitary-gonadal (HPG) axis-related genes, impairing the reproductive capacity of female zebrafish, affecting the development and disrupting the endocrine function of F1. These results suggested that PS-NPs had adverse effects on fish reproductive system both in the directly exposed generation and in their unexposed offspring.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序