Recent and Recurrent Autopolyploidization Fueled Diversification of Snow Carp on the Tibetan Plateau

文献类型： 外文期刊

第一作者： Li, Xinxin

作者： Li, Xinxin;Wang, Min;Zou, Ming;Guan, Xiaotong;Xu, Shaohua;Wang, Chongnv;Guo, Baocheng;Wang, Min;Guan, Xiaotong;Xu, Shaohua;He, Shunping;Guo, Baocheng;Chen, Weitao;Chen, Yiyu;He, Shunping;Chen, Yiyu;Guo, Baocheng

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关键词： whole-genome duplication; speciation; ohnolog; gene tree; isoform sequencing

期刊名称：MOLECULAR BIOLOGY AND EVOLUTION （ 影响因子：5.3； 五年影响因子：11.9 ）

ISSN： 0737-4038

年卷期： 2024 年 41 卷 11 期

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收录情况： SCI

摘要： Whole-genome duplication (WGD), or polyploidization, is a major contributor to biodiversity. However, the establishment and survival of WGDs are often considered to be stochastic, since elucidating the processes of WGD establishment remains challenging. In the current study, we explored the processes leading to polyploidy establishment in snow carp (Cyprinidae: Schizothoracinae), a predominant component of the ichthyofauna of the Tibetan Plateau and its surrounding areas. Using large-scale genomic data from isoform sequencing, we analyzed ohnolog genealogies and divergence in hundreds to thousands of gene families across major snow carp lineages. Our findings demonstrated that independent autopolyploidization subsequent to speciation was prevalent, while autopolyploidization followed by speciation also occurred in the diversification of snow carp. This was further supported by matrilineal divergence and drainage evolution evidence. Contrary to the long-standing hypothesis that ancient polyploidization preceded the diversification of snow carp, we determined that polyploidy in extant snow carp was established by recurrent autopolyploidization events during the Pleistocene. These findings indicate that the diversification of extant snow carp resembles a coordinated duet: first, the uplift of the Tibetan Plateau orchestrated the biogeography and diversification of their diploid progenitors; then, the extensive Pliocene-Pleistocene climate changes acted as relay runners, further fueling diversification through recurrent autopolyploidization. Overall, this study not only reveals a hitherto unrecognized recent WGD lineage in vertebrates but also advances current understanding of WGD processes, emphasizing that WGD establishment is a nonstochastic event, emerging from numerous adaptations to environmental challenges and recurring throughout evolutionary history rather than merely in plants.

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