Single-nucleus and spatial transcriptomics identify brain landscape of gene regulatory networks associated with behavioral maturation in honeybees

文献类型： 外文期刊

第一作者： Mu, Xiaohuan

作者： Mu, Xiaohuan;Lang, Haoyu;Hu, Xiaosong;Zheng, Hao;Zhang, Zijing;Liu, Qun;Ma, Jie;Qin, Yating;Zhang, Yingying;Zhang, Nannan;Li, Denghui;Zhang, Ruihua;Ji, Qianyue;Jiang, Aijun;Pan, Shanshan;Liu, Xiawei;Liu, Xuemei;Sun, Jiahui;Meng, Liang;Liu, Junnian;Liu, Shanshan;Guo, Qunfei;Zhang, Pei;Wang, Yang;Lu, Haorong;Zhang, He;Li, Qiye;Yang, Huanming;Wang, Jian;Xu, Xun;Guo, Qunfei;Zhang, Ruihua;Li, Qiye;Liu, Yan;Chen, Hao;Zheng, Li;Zhai, Yifan

作者机构：

期刊名称：NATURE COMMUNICATIONS （ 影响因子：15.7； 五年影响因子：17.2 ）

ISSN：

年卷期： 2025 年 16 卷 1 期

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收录情况： SCI

摘要： Animal behavior is linked to the gene regulatory network (GRN) coordinating gene expression in the brain. Eusocial honeybees, with their natural behavioral plasticity, provide an excellent model for exploring the connection between brain activity and behavior. Using single-nucleus RNA sequencing and spatial transcriptomics, we analyze the expression patterns of brain cells associated with the behavioral maturation from nursing to foraging. Integrating spatial and cellular data uncovered cell-type and spatial heterogeneity in GRN organization. Interestingly, the stripe regulon is explicitly activated in foragers' small Keyon cells, which are implicated in spatial learning and navigation. When worker age is controlled in artificial colonies, stripe and its key targets remained highly expressed in the KC regions of bees performing foraging tasks. These findings suggest that specific GRNs coordinate individual brain cell activity during behavioral transitions, shedding light on GRN-driven brain heterogeneity and its role in the division of labor of social life.

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