Gut microbiota dysbiosis exaggerates ammonia-induced tracheal injury Via TLR4 signaling pathway

文献类型： 外文期刊

第一作者： Zhou, Ying

作者： Zhou, Ying;Zhao, Xin;Zhang, Minhong;Feng, Jinghai

作者机构：

关键词： Ammonia; Gut microbiota; Tracheal injury; TLR4 signaling pathway; Broiler

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：7.129； 五年影响因子：7.284 ）

ISSN： 0147-6513

年卷期： 2022 年 246 卷

页码：

收录情况： SCI

摘要： Ammonia is a toxic air pollutant that causes severe respiratory tract injury in animals and humans. Gut microbiota dysbiosis has been found to be involved in the development of respiratory tract injury induced by air pollutants, however, the specific mechanism requires investigation. Here, we found that, inhaled ammonia induced tracheal injury by reducing expression of claudin-1, increasing expression of muc5ac, TLR4, MyD88, NF-kappa B and cytokines (TNF-alpha, IL-1 beta, IL-6 and IL-10), and also altering tracheal microbiota composition. Spearman correlation analysis indicated that gut microbiota dysbiosis positively correlated with TLR4 level in the trachea. Antibiotic depletion intestinal microbiota treatment reduced the severity of ammonia-induced tracheal injury via TLR4 signaling pathway. Microbiota transplantation induced the tracheal injury via TLR4 signaling pathway even without the ammonia exposure. These results indicate that gut microbiota dysbiosis exaggerates ammonia-induced tracheal injury via TLR4 signaling pathway. In addition, the [Ruminococcus]_torques_group, Faecali-bacterium, unclassified_f_Lachnospiraceae may be the key gut microbiota contributing to the alterations of tracheal microbiota composition.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序