Dose-dependent effects of apple pectin on alleviating high fat-induced obesity modulated by gut microbiota and SCFAs

文献类型： 外文期刊

第一作者： Zhao, Yuanyuan

作者： Zhao, Yuanyuan;Bi, Jinfeng;Yi, Jianyong;Peng, Jian;Ma, Qiancheng;Peng, Jian;Ma, Qiancheng

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关键词： Pectin; Dosage; Obesity; Gut microbiota; Short-chain fatty acid

期刊名称：FOOD SCIENCE AND HUMAN WELLNESS （ 影响因子：8.022； ）

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年卷期： 2022 年 11 卷 1 期

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收录情况： SCI

摘要： Recently, pectin has been used as an alternative for commercial prebiotic products to modulate gut microbiota. In this study, the standard diet (Chow group) and high fat diet containing 0% (HF group), 1%, 3%, 5%, 8% or 12% (m/m) apple pectin (HF-P group) were offered ad libitum for 8 weeks to 4-week C57BL/6J mice (n = 10/group). Results showed that body weight gain (R-2 = -0.990), subcutaneous adipose accumulation (R-2 = -0.930), serum triglyceride elevation (R-2 = -0.879), acetate (R-2 = 0.955) and propionate concentration reduction (R-2 = 0.985) were suppressed by pectin from 1% to 12%, indicating dose response to pectin consumption. Moreover, abundance of obesity-related bacteria Coriobacteriaceae, and pectin-degradating bacteria, Faecalibaculum, Ruminococcus R-2 were 0.936, 0.963 and 0.937, respectively. Besides, attenuations for colonic injury and liver steatosis were observed after adding 5% and 8% obesity by modulating gut microbiota and enhancing short-chain fatty acids production. (C) 2021 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

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