Distribution and Elimination of Deltamethrin Toxicity in Laying Hens

文献类型： 外文期刊

第一作者： Liu, Yiming

作者： Liu, Yiming;Liu, Chunshuang;Han, Mingyue;Yu, Na;Li, Xiubo;Liu, Yiming;Liu, Chunshuang;Han, Mingyue;Yu, Na;Li, Xiubo;Liu, Yiming;Liu, Chunshuang;Han, Mingyue;Yu, Na;Wang, Jie;Fan, Zhiying;Wang, Wei;Li, Xiubo;Gu, Xu;Pan, Wen

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关键词： deltamethrin; GC-MS; laying hens; residue enrichment; residue elimination

期刊名称：FOODS （ 影响因子：5.2； 五年影响因子：5.5 ）

ISSN：

年卷期： 2023 年 12 卷 24 期

页码：

收录情况： SCI

摘要： Deltamethrin, an important pyrethroid insecticide, is frequently detected in human samples. This study aims to assess the potential effects of deltamethrin on human health and investigate the patterns of residue enrichment and elimination in 112 healthy laying hens. These hens were administered 20 mg center dot kg-1 deltamethrin based on their body weight. Gas chromatography-mass spectrometry (GC-MS) was used to investigate the residue enrichment pattern and elimination pattern of deltamethrin in the hens. The results indicated a significant increase in the concentration of deltamethrin in chicken manure during the treatment period. By the 14th day of administration, the concentration of deltamethrin in the stool reached 13,510.9 +/- 172.24 mu g center dot kg-1, with a fecal excretion rate of 67.56%. The pulmonary deltamethrin concentration was the second highest at 3844.98 +/- 297.14 mu g center dot kg-1. These findings suggest that chicken feces contain substantial amounts of deltamethrin after 14 days of continuous administration, and that it can easily transfer to the lungs. After 21 days of drug withdrawal, the residual concentration of deltamethrin in the fat of laying hens was 904.25 +/- 295.32 mu g center dot kg-1, with a half-life of 17 days and a slow elimination rate. In contrast, the lungs showed relatively low elimination half-lives of 0.2083 days, indicating faster elimination of deltamethrin in this tissue. These results highlight differences in the rate of deltamethrin elimination in different tissues during drug withdrawal. The fat of laying hens exhibited the highest residue of deltamethrin and the slowest elimination rate, while the lungs showed the fastest elimination rate. Moreover, deltamethrin was found to accumulate in the edible tissues of eggs and laying hens, suggesting that humans may be exposed to deltamethrin through food.

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