Sub-chronic, low dose co-exposure to Aflatoxin B-1 and Microcystin-LR in C57BL/6 mice significantly alters the cytokine response in serum and liver

文献类型： 外文期刊

第一作者： Gao, Fuqing

作者： Gao, Fuqing;Li, Yun;Zhao, Haiqing;Liang, Yannei;Liu, Zhe

作者机构：

关键词： Aflatoxin B-1; Microcystin-LR; cytokines; liver injury; the combined effects

期刊名称：CYTA-JOURNAL OF FOOD （ 影响因子：2.478； 五年影响因子：2.905 ）

ISSN： 1947-6337

年卷期： 2022 年 20 卷 1 期

页码：

收录情况： SCI

摘要： In this study, we examined the expression of 11 cytokines in liver and serum of C57BL/6 mice upon single or co-exposed to Aflatoxin B1 and Microcystin-LR at low-dose and sub-chronic conditions. The objective is to elucidate the potential combined hepatotoxic effects induced by AFB1+MC-LR, and we aim to provide references for further immune impacts in the liver. Luminex-based cytokine examination was applied, and we found that most of the cytokine expression increased with time. The level of IL-18, GM-CSF, IFN-gamma, IL-1 beta and IL-4 in the liver showed a significant rise. However, some cytokines (IL-13) showed an upward trend after being suppressed during the middle stage of exposure. The level of IFN-gamma and IL-12p70 generally represented the immune response in the combined exposure group. Conclusionally, there are many uncertainties due to sub-chronic and low-dose exposure. Therefore, the occurrence of subsequent irreversible liver injury and liver cancer is a probabilistic event.

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