Inhibitory Effects of Soluble Dietary Fiber from Foxtail Millet on Colorectal Cancer by the Restoration of Gut Microbiota

文献类型： 外文期刊

第一作者： Zhao, Wenjing

作者： Zhao, Wenjing;Shan, Shuhua;Li, Zhuoyu;Zhao, Wenjing;Ren, Aiqi;Su, Ruijun;Yang, Ruipeng;Zhai, Feihong;Wu, Lihua;Yang, Jieya;Yue, Linzhong;Zhao, Wenjing;Tang, Zhaohui

作者机构： Shanxi Univ, Inst Biotechnol, Key Lab Chem Biol & Mol Engn, Natl Minist Educ, Taiyuan 030006, Peoples R China;Taiyuan Normal Univ, Biol Sci & Technol Coll, Jinzhong 030619, Peoples R China;Shanxi Acad Agr Sci, Taiyuan 030006, Peoples R China

关键词： colorectal cancer; foxtailmillet; solubledietary fiber; gut microbiome; AOM/DSS

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 2022影响因子：6.1； 五年影响因子：6.3 ）

ISSN： 0021-8561

年卷期： 2024 年 72 卷 21 期

页码：

收录情况： SCI

摘要： Colorectal cancer (CRC) is a common malignant tumor that occurs in the colon. Gut microbiota is a complex ecosystem that plays an important role in the pathogenesis of CRC. Our previous studies showed that the soluble dietary fiber of foxtail millet (FMB-SDF) exhibited significant antitumor activity in vitro. The present study evaluated the anticancer potential of FMB-SDF in the azoxymethane (AOM)- and dextran sodium sulfate (DSS)-induced mouse CRC models. The results showed that FMB-SDF could significantly alleviate colon cancer symptoms in mice. Further, we found that FMB-SDF consumption significantly altered gut microbiota diversity and the overall structure and regulated the abundance of some microorganisms in CRC mice. Meanwhile, KEGG pathway enrichment showed that FMB-SDF can also alleviate the occurrence of colon cancer in mice by regulating certain cancer-related signaling pathways. In conclusion, our findings may provide a novel approach for the prevention and biotherapy of CRC.

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