Mechanisms of different sensitivities to 4-hydroxyphenylpyruvate dioxygenase inhibitor benzobicyclon in weedy rice (Oryza sativa f. spontanea)

文献类型： 外文期刊

第一作者： Fang, Jiapeng

作者： Fang, Jiapeng;Yuan, Guohui;Gao, Yuan;Shen, Guohui;Tian, Zhihui

作者机构：

关键词： weedy rice; 4-hydroxyphenylpyruvate dioxygenase inhibitors; differential sensitivity; target-site-based mechanisms; enhanced metabolic detoxification

期刊名称：PEST MANAGEMENT SCIENCE （ 影响因子：3.8； 五年影响因子：4.3 ）

ISSN： 1526-498X

年卷期： 2025 年

页码：

收录情况： SCI

摘要： BACKGROUND: Weedy rice (Oryza sativa f. spontanea) poses considerable challenges to rice production. Benzobicyclon, a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor, has demonstrated potential for controlling weedy rice. However, weedy rice populations exhibit different sensitivities to benzobicyclon and other HPPD inhibitors. Additionally, the genetic and molecular basis of HPPD herbicide sensitivity remains underexplored. Here, we divided weedy rice populations into indica weedy rice (QPAG) and japonica weedy rice (FXYX) and examined the mechanisms behind their varying sensitivity to HPPD inhibitors. RESULTS: Whole-plant dose-response assays showed that the FXYX and QPAG populations had up to >20 times tolerance to benzobicyclon compared to the relatively sensitive population PDRY. Both populations also showed decreased sensitivity to topramezone and pyraquinate. Sequence comparison demonstrated no amino acid mutations in HPPD in any population. The relative expression levels of HPPD did not differ substantially between the populations. Thus, no target site-based mechanisms were present in the weedy rice populations. HPPD INHIBITOR SENSITIVE 1 (HIS 1) was responsible for the reduced sensitivity to benzobicyclon in the FXYX population. Furthermore, P450- and GST-based metabolic mechanisms contributed to lower sensitivity to benzobicyclon to varying degrees in both FXYX and QPAG populations. CONCLUSION: The mechanisms of varying sensitivities to benzobicyclon were different and complex in the japonica and indica weedy rice populations. Increased herbicide metabolism by HIS 1, P450, and GST was the primary mechanism, but varied among the different weedy rice types. Our results provide new insights into the chemical control of different weedy rice types using HPPD inhibitors. (c) 2025 Society of Chemical Industry.

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