Eight new triterpenoids with inhibitory activity against HMG-CoA reductase from the medical mushroom Ganoderma leucocontextum collected in Tibetan plateau

文献类型： 外文期刊

第一作者： Zhang, Jinjin

作者： Zhang, Jinjin;Ma, Ke;Han, Junjie;Wang, Kai;Chen, Hongyu;Bao, Li;Liu, Li;Liu, Hongwei;Zhang, Jinjin;Ma, Ke;Han, Junjie;Wang, Kai;Chen, Hongyu;Bao, Li;Liu, Li;Liu, Hongwei;Xiong, Weiping;Zhang, Yaodong;Huang, Ying

作者机构：

关键词： Ganoderma leucocontextum; Triterpenoids; HMG-CoA reductase inhibitor; Structure-activity relationship

期刊名称：FITOTERAPIA （ 影响因子：3.204； 五年影响因子：3.297 ）

ISSN： 0367-326X

年卷期： 2018 年 130 卷

页码：

收录情况： SCI

摘要： Eight new triterpenoids, ganoleucoins T-Z(1-3, 5-8), and AA (9), together with eleven known triterpenes were isolated and identified from the wild fruiting bodies of the medicinal mushroom Ganoderma leucocontextum. The structures of new compounds were determined on the basis of NMR and MS spectral analysis. The inhibitory effects of 1-9 on HMG-CoA reductase were tested in vitro. Compounds 1, 7 and 8 showed significant HMG-CoA reductase inhibition with IC50 values of 10.2, 9.72 and 8.68 mu M, respectively. The other isolated compounds presented relatively weak inhibitory activity with IC50 values > 100 mu M. Preliminary structure-activity relationship analysis showed that the HMG moiety in 7 and 8 contributed greatly to their inhibitory activity against HMG-CoA reductase. This work further demonstrates the mushroom G. leucocontextum to be valuable herbal medicine that deserves deep investigation.

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