Recent Progress in Phage Therapy to Modulate Multidrug-Resistant Acinetobacter baumannii, including in Human and Poultry

文献类型： 外文期刊

第一作者： Zhang, Yan

作者： Zhang, Yan;Jin, Yajie;Lin, Jiameng;Song, Wuqiang;Li, Tao;Zhang, Yan;Lin, Yuanqing;Fu, Yijuan;Li, Xiuying;Chui, Wenting;Kan, Wei;Jia, Cai;Hu, Guangwei;Galgano, Salvatore;Houdijk, Jos;Xie, Weiquan;Song, Wuqiang

作者机构：

关键词： multidrug-resistant Acinetobacter baumannii; phage therapy

期刊名称：ANTIBIOTICS-BASEL （ 影响因子：5.222； 五年影响因子：5.396 ）

ISSN： 2079-6382

年卷期： 2022 年 11 卷 10 期

页码：

收录情况： SCI

摘要： Acinetobacter baumannii is a multidrug-resistant and invasive pathogen associated with the etiopathology of both an increasing number of nosocomial infections and is of relevance to poultry production systems. Multidrug-resistant Acinetobacter baumannii has been reported in connection to severe challenges to clinical treatment, mostly due to an increased rate of resistance to carbapenems. Amid the possible strategies aiming to reduce the insurgence of antimicrobial resistance, phage therapy has gained particular importance for the treatment of bacterial infections. This review summarizes the different phage-therapy approaches currently in use for multiple-drug resistant Acinetobacter baumannii, including single phage therapy, phage cocktails, phage-antibiotic combination therapy, phage-derived enzymes active on Acinetobacter baumannii and some novel technologies based on phage interventions. Although phage therapy represents a potential treatment solution for multidrug-resistant Acinetobacter baumannii, further research is needed to unravel some unanswered questions, especially in regard to its in vivo applications, before possible routine clinical use.

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