Chemical structure and anti-inflammatory activity of a branched polysaccharide isolated from Phellinus baumii

文献类型： 外文期刊

第一作者： Sun, Yuqing

作者： Sun, Yuqing;Huo, Jinxi;Zhong, Shi;Zhu, Jianxun;Li, Yougui;Li, Xiaojun

作者机构：

关键词： Phellinus baumii; Polysaccharide; Structure; Anti-inflammatory activity; Inflammatory bowel disease

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：9.381； 五年影响因子：8.678 ）

ISSN： 0144-8617

年卷期： 2021 年 268 卷

页码：

收录情况： SCI

摘要： Phellinus baumii is used to treat inflammatory bowel disease (IBD) and gastroenteritis. In this study, a 46 kDa heteropolysaccharide SHPS-1 was isolated from fruiting bodies of P. baumii. SHPS-1 consisted of arabinose, mannose, glucose, and galactose at a molar ratio of 2.2:15.7:49.3:32.8. SHPS-1 had a backbone containing 1,3linked 8-D-Glcp and 1,6-linked alpha-D-Galp residues, and Araf, Manp and Galp units were attached as oligosaccharidic side chains to the backbone at C-6 of some glucopyranoses. SHPS-1 decreased phosphorylation level of STAT-1 and expression levels of STAT-1 targeted genes such as iNOS and TNF-alpha in lipopolysaccharidestimulated macrophage RAW 264.7 cells. Furthermore, SHPS-1 promoted the expression of IL-10 and macrophage mannose receptor CD 206, markers of tissue repairing macrophages. SHPS-1 alleviated ulcerative colitis in mice by decreasing pro-inflammatory genes and increasing anti-inflammatory and tissue repairing genes. Collectively, SHPS-1 polysaccharide from P. baumii had anti-inflammatory activity and can potentially treat IBD.

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