Uncovering Evolutionary Adaptations in Common Warthogs through Genomic Analyses

文献类型： 外文期刊

第一作者： Yang, Xintong

作者： Yang, Xintong;Li, Xingzheng;Bao, Qi;Wang, Zhen;He, Sang;Qu, Xiaolu;Tang, Yueting;Song, Bangmin;Yi, Guoqiang;Yang, Xintong;Huang, Jieping;Tang, Yueting;Song, Bangmin;Yi, Guoqiang;Yi, Guoqiang

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关键词： warthog; gene family; phylogenetic relationships; divergence; phenotype; QTL

期刊名称：GENES （ 影响因子：3.5； 五年影响因子：3.9 ）

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年卷期： 2024 年 15 卷 2 期

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收录情况： SCI

摘要： In the Suidae family, warthogs show significant survival adaptability and trait specificity. This study offers a comparative genomic analysis between the warthog and other Suidae species, including the Luchuan pig, Duroc pig, and Red River hog. By integrating the four genomes with sequences from the other four species, we identified 8868 single-copy orthologous genes. Based on 8868 orthologous protein sequences, phylogenetic assessments highlighted divergence timelines and unique evolutionary branches within suid species. Warthogs exist on different evolutionary branches compared to DRCs and LCs, with a divergence time preceding that of DRC and LC. Contraction and expansion analyses of warthog gene families have been conducted to elucidate the mechanisms of their evolutionary adaptations. Using GO, KEGG, and MGI databases, warthogs showed a preference for expansion in sensory genes and contraction in metabolic genes, underscoring phenotypic diversity and adaptive evolution direction. Associating genes with the QTLdb-pigSS11 database revealed links between gene families and immunity traits. The overlap of olfactory genes in immune-related QTL regions highlighted their importance in evolutionary adaptations. This work highlights the unique evolutionary strategies and adaptive mechanisms of warthogs, guiding future research into the distinct adaptability and disease resistance in pigs, particularly focusing on traits such as resistance to African Swine Fever Virus.

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