文献类型： 外文期刊

第一作者： Jianzhong, S

作者： Jianzhong, S;Xiubo, L;Haiyang, J;Walter, HH

作者机构：

期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.786； 五年影响因子：1.7 ）

ISSN： 0140-7783

年卷期： 2004 年 27 卷 3 期

页码：

收录情况： SCI

摘要： A study on bioavailability and pharmacokinetics of florfenicol was conducted in 20 crossbred healthy sheep following a single intravenous (i.v.) and intramuscular (i.m.) doses of 20 and 30 mg/kg body weight (b.w.). Florfenicol concentrations in serum were determined by a validated high-performance liquid chromatography method with UV detection at a wavelength of 223 nm in which serum samples were spiked with chloramphenicol as internal standard. Serum concentration-time data after i.v. administration were best described by a three-compartment open model with values for the distribution half-lives (T-1/2alpha) 1.51 +/- 0.06 and 1.59 +/- 0.10 h, elimination half-lives (T-1/2beta) 18.83 +/- 6.76 and 18.71 +/- 1.85 h, total body clearance (Cl-B) 0.26 +/- 0.03 and 0.25 +/- 0.01 L/kg/h, volume of distribution at steady-state (V-d(ss)) 1.86 +/- 0.11 and 1.71 +/- 0.20 L/kg, area under curve (AUC) 76.31 +/- 9.17 and 119.21 +/- 2.05 mug.h/mL after i.v. injections of 20 and 30 mg/kg b.w. respectively. Serum concentration-time data after i.m. administration were adequately described by a one-compartment open model. The pharmacokinetic parameters were distribution half-lives (T-1/2ka) 0.27 +/- 0.03 and 0.25 +/- 0.09 h, elimination half-lives (T-1/2ke) 10.34 +/- 1.11 and 9.57 +/- 2.84 h, maximum concentrations (C-max) 4.13 +/- 0.29 and 7.04 +/- 1.61 mug/mL, area under curve (AUC) 67.95 +/- 9.61 and 101.95 +/- 8.92 mug.h/mL, bioavailability (F) 89.04% and 85.52% after i.m. injections of 20 and 30 mg/kg b.w. respectively.

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