Characterization of thymus atrophy in piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus

文献类型: 外文期刊

第一作者: He, Yuli

作者: He, Yuli;Wang, Gang;Liu, Yonggang;Shi, Wenda;Han, Zifeng;Wu, Jianan;Jiang, Chenggang;Wang, Shujie;Hu, Shouping;Wen, Huiqiang;Dong, Jianguo;Liu, He;Cai, Xuehui

作者机构:

关键词: Highly pathogenic PRRSV;PRRSV;Thymus atrophy;Apoptosis;Ultrastructure

期刊名称:VETERINARY MICROBIOLOGY ( 影响因子:3.293; 五年影响因子:3.599 )

ISSN: 0378-1135

年卷期: 2012 年 160 卷 3-4 期

页码:

收录情况: SCI

摘要: Our previous study has demonstrated that piglets infected with highly pathogenic PRRSV (HP-PRRSV) induced significant thymus atrophy. The aim of this study was to further investigate the lesions in thymus of piglets infected with HP-PRRSV or PRRSV and the changes of thymic T cell populations. The lesions were evaluated for the thymus/body weight ratios, pathological changes and virus load in thymus, apoptosis and ultrastructure of thymocytes. The result showed that thymus/body weight ratios of HP-PRRSV-infected piglets were significantly reduced compared to PRRSV-infected or control piglets, and thymic lesions were characterized by severe cortical depletion of thymocytes. The number of thymocytes undergoing apoptosis was increased approximately forty-fold in piglets infected with HP-PRRSV than that of PRRSV on 7 days post-inoculation (DPI). Double-positive thymocytes of piglets infected with HP-PRRSV were suppressed to a greater degree than either single positive subpopulation, but similar results were not observed in piglets infected with PRRSV. These results suggested that HP-PRRSV induced abundant apoptosis might result in severe thymus atrophy and the depletion of thymocytes. (C) 2012 Elsevier B.V. All rights reserved.

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