Comparative Analysis of Immune Responses in Pigs to High and Low Pathogenic Porcine Reproductive and Respiratory Syndrome Viruses Isolated in China

文献类型： 外文期刊

第一作者： Han, Z.

作者： Han, Z.;Liu, Y.;Wang, G.;He, Y.;Hu, S.;Li, Y.;Shi, W.;Wu, J.;Wang, S.;Liu, H.;Cai, X.

作者机构：

关键词： highly pathogenic porcine reproductive and respiratory syndrome virus;porcine reproductive and respiratory syndrome virus;cytokines;immunity modulation

期刊名称：TRANSBOUNDARY AND EMERGING DISEASES （ 影响因子：5.005； 五年影响因子：4.622 ）

ISSN： 1865-1674

年卷期： 2015 年 62 卷 5 期

页码：

收录情况： SCI

摘要： The CH-1a and HuN4 strains of porcine reproductive and respiratory syndrome virus (PRRSV) show different pathogenicities in pigs. To understand host immune responses against these viruses, we investigated the dynamic changes in cytokine levels produced in peripheral blood of piglets infected with the highly pathogenic PRRSV HuN4 strain or the CH-1a strain. Clinical signs, virus loads and serum cytokine levels [interferon(IFN)-, Interleukin (IL)-1, TNF-, IL-6, IL-12, IFN-, IL-10 and TGF-] were tested. The results showed that while piglets developed effective cellular immune responses against CH-1a infection, those infected with HuN4 displayed ineffective cellular immunity, organ lesions and persistent elevated levels of immunoregulatory cytokines (IL-10 and TGF-), which delayed the development of PRRSV-specific immune responses. These results demonstrated that HuN4 infection induced higher cytokine levels than that of CH-1a infection induced. The changes in inflammatory cytokines intensified the inflammatory reaction and damaged the tissues and organs.

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