Genetic and biological characterization of two novel reassortant H5N6 swine influenza viruses in mice and chickens

文献类型： 外文期刊

第一作者： Li, Xuyong

作者： Li, Xuyong;Fu, Yuguang;Yang, Jiayun;Guo, Jing;He, Jijun;Guo, Jianhong;Weng, Shaoting;Jia, Yane;Liu, Bin;Li, Xiaoyang;Zhu, Qiyun;Chen, Hualan

作者机构：

关键词： Influenza virus;H5N6;Swine;Reassortment;Public health

期刊名称：INFECTION GENETICS AND EVOLUTION （ 影响因子：3.342； 五年影响因子：3.188 ）

ISSN： 1567-1348

年卷期： 2015 年 36 卷

页码：

收录情况： SCI

摘要： Novel H5N6 influenza A viruses have infected birds and human beings and caused four human clinical cases in China since 2014. The pig, as a mixing vessel, plays an important role for influenza virus reassortment and transmission. Towards this, routine surveillance for swine influenza in Guangdong province was conducted in 2014. In this study, we reported the biological characterization of two H5N6 influenza viruses isolated from healthy pigs in Guangdong province. Genetic analysis indicates that the two viruses are reassortants of 2.3.4.4 H5N1 and H6N6 avian influenza viruses with a high similarity to duck and human H5N6 influenza viruses isolated from Guangdong province. The data from chicken and mouse experiments show that the viruses are highly pathogenic in chickens and result in a systemic infection, and replicate in the mouse lung accompanying with a clinical inflammatory pathology. The results of the study demonstrate that the two H5N6 influenza viruses isolated from swine are the avian-originated viruses and have not adapted to swine population yet. However, they might keep evolving and pose a potential risk to public health and the continued surveillance of swine influenza should be strengthened. (C) 2015 Elsevier B.V. All rights reserved.

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