Recombinant duck enteritis virus works as a single-dose vaccine in broilers providing rapid protection against H5N1 influenza infection

文献类型： 外文期刊

第一作者： Liu, Jinxiong

作者： Liu, Jinxiong;Chen, Pucheng;Jiang, Yongping;Deng, Guohua;Shi, Jianzhong;Wu, Li;Lin, Yuan;Bu, Zhigao;Chen, Hualan

作者机构：

关键词： Avian influenze;H5N1;Vaccine

期刊名称：ANTIVIRAL RESEARCH （ 影响因子：5.97； 五年影响因子：5.801 ）

ISSN： 0166-3542

年卷期： 2013 年 97 卷 3 期

页码：

收录情况： SCI

摘要： Although vaccination is an important strategy for controlling H5N1 avian influenza virus infections, broilers (short-lived meat chickens) remain the major victims in disease-endemic countries. Inactivated vaccine usually requires 2-3 weeks to establish solid protection, and recombinant vaccines, including the recombinant fowlpox virus vaccine and the recombinant Newcastle disease virus vaccine are affected by maternal antibodies against the vectors. These disadvantages compromise the protective efficacy of these vaccines in broilers. Here, we evaluated the safety and efficacy of a new recombinant duck enteritis virus that expresses the HA gene of an H5N1 virus (rDEV-re6) in specific-pathogen-free chickens and broilers. We found this new rDEV-re6 virus to be safe in chickens and to induce rapid and solid protection after a single dose. This virus may therefore serve as an ideal single-dose vaccine for broilers. (C) 2012 Elsevier B.V. All rights reserved.

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