Two amino acid residues in the matrix protein M1 contribute to the virulence difference of H5N1 avian influenza viruses in mice

文献类型： 外文期刊

第一作者： Fan, Shufang

作者： Fan, Shufang;Deng, Guohua;Song, Jiasheng;Tian, Guobin;Suo, Yongbing;Jiang, Yongping;Guan, Yuntao;Bu, Zhigao;Kawaola, Yoshihiro;Chen, Hualan

作者机构：

关键词： Avian influenza viruses

期刊名称：VIROLOGY （ 影响因子：3.616； 五年影响因子：3.967 ）

ISSN： 0042-6822

年卷期： 2009 年 384 卷 1 期

页码：

收录情况： SCI

摘要： A/duck/Guangxi/53/2002 (DKGX/53) and A/duck/Fujian/01/2002 (DKFJ/01) are H5N1 avian influenza viruses that are lethal in chickens. In mice, however, DKFJ/01 is highly pathogenic, whereas DKGX/53 displays low pathogenicity. In this study, we used reverse genetics to demonstrate that two amino acid residues at positions 30 and 215 of the M1 protein of these two viruses are important determinants for pathogenicity in mice. We thus firstly prove the M1 protein contributes to the virulence of H5N1 viruses in mice, and the amino acid residues shown to attenuate the virulence could be targeted in influenza virus candidates for live vaccine development. (C) 2008 Elsevier Inc. All rights reserved.

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