Effects of cold acclimation on serum biochemical parameters and metabolite profiles in Schizothorax prenanti

文献类型： 外文期刊

第一作者： Wang, Aiyu

作者： Wang, Aiyu;Zhang, Run;Zhang, Xianshu;Chen, Chunjie;Wang, Linjie;Wang, Yan;Gong, Quan

作者机构：

关键词： Cold acclimation; Metabolomics; Amino acids; Unsaturated fatty acids; Schizothorax prenanti

期刊名称：BMC GENOMICS （ 影响因子：4.4； 五年影响因子：4.7 ）

ISSN： 1471-2164

年卷期： 2024 年 25 卷 1 期

页码：

收录情况： SCI

摘要： Background Environmental temperature is critical in regulating biological functions in fish. S. prenanti is a kind of cold-water fish, but of which we have little knowledge about the metabolic adaptation and physiological responses to long-term cold acclimation. Results In this study, we determined the physiological responses of S. prenanti serum after 30 days of exposure to 6degree celsius. Compared with the control group, the levels of TC, TG, and LDL-C in the serum were significantly (P < 0.05) increased, and the level of glucose was significantly (P < 0.05) decreased under cold acclimation. Cold acclimation had no effect on the gene expression of pro-inflammatory factors and anti-inflammatory factors of S. prenanti. Metabolomics analysis by LC-MS showed that a total of 60 differential expressed metabolites were identified after cold acclimation, which involved in biosynthesis of amino acids, biosynthesis of unsaturated fatty acids, steroid degradation, purine metabolism, and citrate cycle pathways. Conclusion The results indicate that cold acclimation can alter serum metabolites and metabolic pathways to alter energy metabolism and provide insights for the physiological regulation of cold-water fish in response to cold acclimation.

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