Advances of functional nucleic acids based on specific recognition:A review

文献类型： 外文期刊

第一作者： Liu, Beibei

作者： Liu, Beibei;Chen, Ge;Zhai, Rongqi;Liu, Guangyang;Xu, Xiaomin;Zhang, Yanguo;Li, Lingyun;Xu, Donghui;Liu, Beibei;Zhang, Jie;Abd El-Aty, A. M.;Abd El-Aty, A. M.

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关键词： Functional nucleic acids; Specific recognition; Application

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）

ISSN： 0141-8130

年卷期： 2025 年 304 卷

页码：

收录情况： SCI

摘要： Nucleic acids, which are fundamental to living organisms, play a crucial role in carrying and transmitting genetic information. Advances in molecular biology have led to the exploration of functional nucleic acids (FNAs), including aptamers, DNAzymes, and G-quadruplexes, known for specific recognition or catalysis. FNAs with high specificity, sequence programmability, modification ease and biocompatibility, have extensive applications in biosensing, environmental monitoring, drug delivery and cancer diagnosis. This review focuses on the structure and specific recognition principles of FNAs, followed by an exploration for biosensing and biomedical applications, offering insights into current challenges and future trends in FNAs as recognition elements.

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