Impacts of co-exposure to zearalenone and trifloxystrobin on the enzymatic activity and gene expression in zebrafish

文献类型： 外文期刊

第一作者： Cang, Tao

作者： Cang, Tao;Wu, Changxing;Liu, Caixiu;Song, Wen;Wang, Yanhua;Chen, Chen;Yu, Yijun

作者机构：

关键词： Mycotoxin; Zebrafish; Biomarker; Synergistic effect

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.8； 五年影响因子：6.9 ）

ISSN： 0147-6513

年卷期： 2023 年 256 卷

页码：

收录情况： SCI

摘要： Although humans and animals are usually exposed to combinations of toxic substances, little is known about the interactive toxicity of mycotoxins and farm chemicals. Therefore, we can not precisely evaluate the health risks of combined exposure. In the present work, using different approaches, we examined the toxic impacts of zearalenone and trifloxystrobin on zebrafish (Danio rerio). Our findings showed that the lethal toxicity of zear-alenone to embryonic fish with a 10-day LC50 of 0.59 mg L-1 was lower than trifloxystrobin (0.037 mg L-1). Besides, the mixture of zearalenone and trifloxystrobin triggered acute synergetic toxicity to embryonic fish. Moreover, the contents of CAT, CYP450, and VTG were distinctly altered in most single and combined exposures. Transcriptional levels of 23 genes involved in the oxidative response, apoptosis, immune, and endocrine systems were determined. Our results implied that eight genes (cas9, apaf-1, bcl-2, il-8, trb, vtg1, er beta 1, and tg) displayed greater changes when exposed to the mixture of zearalenone and trifloxystrobin compared with the corre-sponding individual chemicals. Our findings indicated that performing the risk assessment based on the com-bined impact rather than the individual dosage response of these chemicals was more accurate. Nevertheless, further investigations are still necessary to reveal the modes of action of mycotoxin and pesticide combinations and alleviate their effects on human health.

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