文献类型： 外文期刊
第一作者： Li, Peng
作者： Li, Peng;Wang, Hengtai;Ding, Jiabo;Sun, Wei
作者机构：
关键词： Yersinia pseudotuberculosis; MgtC; intracellular survival; pathogenic
期刊名称：PATHOGENS （ 影响因子：3.7； 五年影响因子：3.7 ）
ISSN：
年卷期： 2023 年 12 卷 12 期
页码：
收录情况： SCI
摘要： Yersinia pseudotuberculosis is an extracellular foodborne pathogen and usually causes self-limiting diarrhea in healthy humans. MgtC is known as a key subversion factor that contributes to intramacrophage adaptation and intracellular survival in certain important pathogens. Whether MgtC influences the fitness of Y. pseudotuberculosis is unclear. According to in silico analysis, MgtC in Y. pseudotuberculosis might share similar functions with other bacterial pathogens, such as Salmonella. Studies indicated that MgtC was clearly required for Y. pseudotuberculosis growth in vitro and bacterial survival in macrophages under Mg2+ starvation. Transcriptome analysis by RNA-seq indicated that 127 differentially expressed genes (DEGs) (fold change > 2 and p < 0.001) were discovered between wild-type PB1+ and mgtC mutant inside macrophages. However, a lack of MgtC only moderately, albeit significantly, reduced the virulence of Y. pseudotuberculosis in mice. Overall, this study provides additional insights for the role of MgtC in Y. pseudotuberculosis.
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