Novel caffeic acid grafted chitosan-sodium alginate microcapsules generated by microfluidic technique for the encapsulation of bioactive peptides from silkworm pupae

文献类型： 外文期刊

第一作者： Xun, Xiao-Meng

作者： Xun, Xiao-Meng;Zhang, Zhi-Ang;Yuan, Zi-Xuan;Tuhong, Kamila;Yan, Cheng-Hai;Zhan, Yu-Fan;Wu, Qiong-Ying;Wang, Jun;Kang, Guo-Ping;Wang, Jun;Wu, Qiong-Ying;Wang, Jun

作者机构：

关键词： Caffeic acid-grafted chitosan; Microfluidic; Silkworm pupae peptides; Microcapsule

期刊名称：SUSTAINABLE CHEMISTRY AND PHARMACY （ 影响因子：6.0； 五年影响因子：5.6 ）

ISSN：

年卷期： 2023 年 32 卷

页码：

收录情况： SCI

摘要： Microcapsules were prepared to develop an environmentally friendly drug carrier using chitosan and caffeic acid-grafted chitosan (CA -g-Ch) as carriers to efficiently encapsulate bioactive pep-tides from silkworm pupae by microfluidics. The optimization of the preparation process resulted in the optimal solution: 0.3% CA -g-Ch, 3% sodium alginate, 0.6% CaCl2, and 40 mg/mL silkworm pupae peptides. The developed microcapsules were analyzed by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), differential scan-ning calorimetry (DSC), and thermogravimetric analysis (TGA). CA -g-Ch-sodium alginate micro -capsules could be used to deliver silkworm pupae bioactive peptides. The encapsulation effi-ciency of CA -g-Ch-sodium alginate microcapsules was enhanced to 96.61 +/- 1.95%, and the ther-mal stability and antioxidant properties of the microcapsules were improved. In gastrointestinal digestion, CA -g-Ch-sodium alginate microcapsules showed good acid resistance and intestinal re-lease. Thus, CA -g-Ch-sodium alginate microcapsules are expected to become environmentally friendly encapsulation carriers for hydrophilic drug delivery.

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