Carriage of Distinct mcr-1-Harboring Plasmids by Unusual Serotypes of Salmonella

文献类型： 外文期刊

第一作者： Tang, Biao

作者： Tang, Biao;Chang, Jiang;Yang, Hua;Tang, Biao;Chang, Jiang;Yang, Hua;Chang, Jiang;Zhang, Ling;Xia, Xiaodong;Liu, Lizhang;Feng, Youjun;Liu, Lizhang;Feng, Youjun;Hassan, Bachar H.;Jia, Xu;Feng, Youjun;Feng, Youjun

作者机构：

关键词： IncHI2; IncX4; mcr-1; Salmonella Ngor; Salmonella Goldcoast

期刊名称：ADVANCED BIOSYSTEMS

ISSN：

年卷期： 2020 年 4 卷 3 期

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收录情况： SCI

摘要： Colistin acts as a last-resort antibiotic against lethal infections by carbapenem-resistant Enterobacterial pathogens. Enterobacteriaceae carrying mobile colistin resistance (MCR) genes are rapidly emerging and threatening human health and food safety. Despite mcr-1 being prevalent in Escherichia coli, its dissemination in Salmonella is not well characterized. Herein, two unusual serotypes of colistin-resistant Salmonella isolates are reported first, namely serotype Ngor (ST5399) and Goldcoast (ST2529). Using whole genome sequencing, it is shown that mcr-1 is located on the IncHI2-like plasmid pTB501 (188,527 bp) of strain SSDFZ54 and the IncX4-type plasmid pTB602 (33,303 bp) in strain SSDFZ69, respectively. Furthermore, the backbone, tra- and antimicrobial resistance genes relative variable regions in the mcr-1-bearing IncHI2 plasmids are systematically characterized. Phylogenetic analysis shows that all IncHI2-type plasmids from non-Chinese regions are clustered together, suggesting a possible Chinese origin. Taken together, these findings extend the understanding of Salmonella as a vehicle of mcr-1 carriage and distribution.

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