Toxic effects of waterborne lead (Pb) on bioaccumulation, serum biochemistry, oxidative stress and heat shock protein-related genes expression in Channa argus

文献类型： 外文期刊

第一作者： Zhao, Lei

作者： Zhao, Lei;Li, Mu-Yang;Zhao, Lei;Wang, Gui-Qin;Zheng, Ya-Guang;Feng, Yong-Hui;Ma, Yan-Fen

作者机构：

关键词： Pb; Oxidative stress; Immune response; HSPs gene expression

期刊名称：CHEMOSPHERE （ 影响因子：7.086； 五年影响因子：6.956 ）

ISSN： 0045-6535

年卷期： 2020 年 261 卷

页码：

收录情况： SCI

摘要： Lead (Pb) is a harmful metal element for aquatic animals. The aim of this study was to determine waterborne Pb exposure on oxidative stress, serum biochemistry and heat shock proteins (HSPs) genes expression in Channa argus. Fish were randomly divided into four groups and the Pb concentrations were 0, 50, 200, and 800 mu g/L, respectively. The results showed that the accumulation of Pb was detected in the gill, intestine, liver and muscle following exposure to Pb. Pb accumulation content in tissues was gill > intestinal > liver > muscle. With the increased of Pb exposure concentrations, the levels of catalase (CAT), glutathione peroxidase (GPx), lysozyme (LZM) and immunoglobulin M (IgM) significantly decreased. Serum biochemistry, oxidative stress parameters and HSPs gene expression were all enhanced with the increase following Pb expose concentration. Our results suggest that waterborne Pb exposure can induce Pb accumulation, oxidative stress and immune response in C. argus. (C) 2020 Elsevier Ltd. All rights reserved.

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