Identification of Immune Response to Sacbrood Virus Infection in Apis cerana Under Natural Condition

文献类型： 外文期刊

第一作者： Deng, Yanchun

作者： Deng, Yanchun;Yang, Sa;Yang, Dahe;Deng, Shuai;Hou, Chunsheng;Deng, Yanchun;Yang, Sa;Yang, Dahe;Deng, Shuai;Hou, Chunsheng;Deng, Yanchun;Zhao, Hongxia;Shen, Shuo

作者机构：

关键词： Chinese sacbrood virus; serine protease; Apis cerana; transcriptome; siRNA; immune response

期刊名称：FRONTIERS IN GENETICS （ 影响因子：4.599； 五年影响因子：4.888 ）

ISSN：

年卷期： 2020 年 11 卷

页码：

收录情况： SCI

摘要： Chinese sacbrood virus (CSBV) is a serious threat to eastern honeybees (Apis cerana), especially larvae. However, the pathological mechanism of this deadly disease remains unclear. Here, we employed mRNA and small RNA (sRNA) transcriptome approach to investigate the microRNAs (miRNAs) and small interfering RNAs (siRNAs) expression changes of A. cerana larvae infected with CSBV under natural condition. We found that serine proteases involved in immune response were down-regulated, while the expression of siRNAs targeted to serine proteases were up-regulated. In addition, CSBV infection also affected the expression of larvae cuticle proteins such as larval cuticle proteins A1A and A3A, resulting in increased susceptibility to CSBV infection. Together, our results provide insights into sRNAs that they are likely to be involved in regulating honeybee immune response.

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