文献类型： 外文期刊
第一作者： Lu, Juanli
作者： Lu, Juanli;Li, Guangyu;Wang, Ruiqi;Liu, Yingxin;Duan, Cunyu;Duan, Shiyun;He, Xuanyi;Huang, Zhuo;Wu, Qin;Yang, Qing;Yang, Qing;Peng, Xitian;Yan, Wei;Jiang, Jinhua
作者机构：
关键词： Beta-cypermethrin; Zebrafish; Reproduction; HPG axis; Molecular mechanisms
期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY （ 影响因子：3.228； 五年影响因子：3.289 ）
ISSN： 1532-0456
年卷期： 2021 年 239 卷
页码：
收录情况： SCI
摘要： Beta-cypermethrin, a type II synthetic pyrethroid insecticide, is widely used in pest control. Several studies have demonstrated that beta-cypermethrin can affect the reproductive system of mammals. However, there is still a scarcity of information about the reproductive toxicity to fish induced by beta-cypermethrin and its molecular mechanism. Therefore, this study was conducted to address this scientific question, in which the adult zebrafish were exposed to 0 (blank control), 0 (acetone solvent control), 0.1, 0.5, and 2.5 mu g/L of beta-cypermethrin for 21 days. A decrease in cumulative egg production of zebrafish was observed, indicating that beta-cypermethrin had a negative impact on reproductive capacity of zebrafish. Regarding the histomorphological analysis of gonads, the delay of gonadal development was observed after exposure for 21 days. In addition, significant changes in plasma 17 beta-estradiol (E2) and testosterone (T) were found in zebrafish. Further exploration showed that the transcription levels of hypothalamic-pituitary-gonadal (HPG) axis-related genes were remarkably changed, which corresponded well with the alterations of hormone levels. These results demonstrated that beta-cypermethrin might have an adverse effect on the reproduction system of zebrafish through delaying gonadal development, disturbing sex hormone secretion, and affecting HPG axis gene expression. This study suggests that beta-cypermethrin poses a potential threat to the reproduction of fish populations, and the toxicity assessment of beta-cypermethrin plays a vital role in the environmental risk assessment of pesticides.
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