Marek's Disease Virus (Gallid alphaherpesvirus 2)-Encoded miR-M2-5p Simultaneously Promotes Cell Proliferation and Suppresses Apoptosis Through RBM24 and MYOD1-Mediated Signaling Pathways

文献类型： 外文期刊

第一作者： Zhu, Zhi-Jian

作者： Zhu, Zhi-Jian;Zhu, Zhi-Jian;Teng, Man;Li, Hui-Zhen;Zheng, Lu-Ping;Liu, Jin-Ling;Chai, Shu-Jun;Luo, Jun;Zhu, Zhi-Jian;Teng, Man;Li, Hui-Zhen;Zheng, Lu-Ping;Liu, Jin-Ling;Chai, Shu-Jun;Luo, Jun;Zhu, Zhi-Jian;Teng, Man;Li, Hui-Zhen;Zheng, Lu-Ping;Liu, Jin-Ling;Chai, Shu-Jun;Luo, Jun;Li, Hui-Zhen;Zhang, Gai-Ping;Yao, Yong-Xiu;Nair, Venugopal;Yao, Yong-Xiu;Nair, Venugopal;Zhang, Gai-Ping;Luo, Jun

作者机构：

关键词： herpesvirus; Gallid alphaherpesvirus 2; oncogenesis; miRNA; miR-M2-5p; RNA-binding protein 24; myogenic differentiation 1; Marek’ s disease

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.64； 五年影响因子：6.32 ）

ISSN： 1664-302X

年卷期： 2020 年 11 卷

页码：

收录情况： SCI

摘要： MicroRNAs (miRNAs) have been demonstrated for their involvement in virus biology and pathogenesis, including functioning as key determinants of virally-induced cancers. As an important oncogenic alpha-herpesvirus affecting poultry health, Marek's disease virus serotype 1 [Gallid alphaherpesvirus 2 (GaHV-2)] induces rapid-onset T-cell lymphomatous disease commonly referred to as Marek's disease (MD), an excellent biological model for the study of virally-induced cancer in the natural hosts. Previously, we have demonstrated that GaHV-2-encoded miRNAs (especially those within the Meq-cluster) have the potential to act as critical regulators of multiple processes such as virus replication, latency, pathogenesis, and/or oncogenesis. In addition to miR-M4-5p (miR-155 homolog) and miR-M3-5p, we have recently found that miR-M2-5p possibly participate in inducing MD lymphomagenesis. Here, we report the identification of two tumor suppressors, the RNA-binding protein 24 (RBM24) and myogenic differentiation 1 (MYOD1), being two biological targets for miR-M2-5p. Our experiments revealed that as a critical miRNA, miR-M2-5p promotes cell proliferation via regulating the RBM24-mediated p63 overexpression and MYOD1-mediated IGF2 signaling and suppresses apoptosis by targeting the MYOD1-mediated Caspase-3 signaling pathway. Our data present a new strategy of a single viral miRNA exerting dual role to potentially participate in the virally-induced T-cell lymphomagenesis by simultaneously promoting the cell proliferation and suppressing apoptosis.

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