文献类型： 外文期刊
第一作者： Shan, Qiang
作者： Shan, Qiang;Ma, Fengtao;Wei, Jingya;Li, Hongyang;Sun, Peng;Ma, Hui
作者机构：
关键词： Heat shock proteins; molecular chaperone; immunity; antioxidation; tumor; heat shock factor
期刊名称：CURRENT PROTEIN & PEPTIDE SCIENCE （ 影响因子：3.272； 五年影响因子：3.183 ）
ISSN： 1389-2037
年卷期： 2020 年 21 卷 8 期
页码：
收录情况： SCI
摘要： Heat shock proteins (HSPs) are molecular chaperones involved in a variety of life activities. HSPs function in the refolding of misfolded proteins, thereby contributing to the maintenance of cellular homeostasis. Heat shock factor (HSF) is activated in response to environmental stresses and binds to heat shock elements (HSEs), promoting HSP translation and thus the production of high levels of HSPs to prevent damage to the organism. Here, we summarize the role of molecular chaperones as anti-heat stress molecules and their involvement in immune responses and the modulation of apoptosis. In addition, we review the potential application of HSPs to cancer therapy, general medicine, and the treatment of heart disease.
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