文献类型： 外文期刊
第一作者： Zheng, Chen
作者： Zheng, Chen;Liu, Ting;Liu, Huihui;Wang, Jing
作者机构：
关键词： BCL-2 family proteins; apoptosis; regulation; nutrients; lymphoma; probiotics
期刊名称：CURRENT PROTEIN & PEPTIDE SCIENCE （ 影响因子：3.272； 五年影响因子：3.183 ）
ISSN： 1389-2037
年卷期： 2020 年 21 卷 8 期
页码：
收录情况： SCI
摘要： In the body, millions of cells die and proliferate each day to maintain normal function and cooperation of all tissues, organs, and systems. Thus, programmed cell death, or apoptosis, is critical to sustain growth, development, and body health. The vital role of B-cell leukemia/lymphoma-2 (BCL-2) family proteins in apoptosis has been identified. The BCL-2 family includes both pro- and antiapoptotic proteins, which are structurally and functionally related, containing up to four BCL-2 homology (BH) motifs (BH1-4). There are also some nutritional factors that regulate apoptosis via the BCL-2 family proteins. In this review, the BCL-2 family proteins and their apoptosis-inducing mechanism have been discussed, along with the nutrient factors that regulate apoptosis through the BCL-2 family proteins.
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