PRE-1 Revealed Previous Unknown Introgression Events in Eurasian Boars during the Middle Pleistocene

文献类型： 外文期刊

第一作者： Zhao, Pengju

作者： Zhao, Pengju;Du, Heng;Zheng, Xianrui;Feng, Wen;Diao, Chenguang;Zhou, Lei;Zhang, Hao;Zhang, Qin;Liu, Jian-Feng;Zhao, Pengju;Du, Heng;Zheng, Xianrui;Feng, Wen;Diao, Chenguang;Zhou, Lei;Zhang, Hao;Zhang, Qin;Liu, Jian-Feng;Jiang, Lin;Liu, George E.;Chamba, Yangzom;Zhang, Qin;Li, Bugao

作者机构：

关键词： pigs; transposable elements; PRE1-SS; population admixture and divergence

期刊名称：GENOME BIOLOGY AND EVOLUTION （ 影响因子：3.416； 五年影响因子：4.079 ）

ISSN： 1759-6653

年卷期： 2020 年 12 卷 10 期

页码：

收录情况： SCI

摘要： Introgression events and population admixture occurred among Sus species across the Eurasian mainland in the Middle Pleistocene, which reflects the local adaption of different populations and contributes to evolutionary novelty. Previous findings on these population introgressions were largely based on extensive genome-wide single-nucleotide polymorphism information, ignoring structural variants (SVs) as an important alternative resource of genetic variations. Here, we profiled the genome-wide SVs and explored the formation of pattern-related SVs, indicating that PRE1-SS is a recently active subfamily that was strongly associated with introgression events in multiple Asian and European pig populations. As reflected by the three different combination haplotypes from two specific patterns and known phylogenetic relationships in Eurasian boars, we identified the Asian Northern wild pigs as having experienced introgression from European wild boars around 0.5-0.2 Ma and having received latitude-related selection. During further exploration of the influence of pattern-related SVs on gene functions, we found substantial sequence changes in 199 intron regions of 54 genes and 3 exon regions of 3 genes (HDX, TRO, and SMIM1), implying that the pattern-related SVs were highly related to positive selection and adaption of pigs. Our findings revealed novel introgression events in Eurasian wild boars, providing a timeline of population admixture and divergence across the Eurasian mainland in the Middle Pleistocene.

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