An in-vitro study on a novel six-phage cocktail against multi-drug resistant-ESBL Shigella in aquatic environment

文献类型： 外文期刊

第一作者： Shahin, K.

作者： Shahin, K.;Zhang, L.;Bao, H.;Soleimani-Delfan, A.;He, T.;Barazandeh, M.;Wang, R.;Hedayatkhah, A.;Komijani, M.;Mansoorianfar, M.;Bouzari, M.

作者机构：

关键词： bacteriophage; bio‐ control; in‐ vitro; phage; phage cocktail; Shigella; water‐ borne

期刊名称：LETTERS IN APPLIED MICROBIOLOGY （ 影响因子：2.858； 五年影响因子：2.776 ）

ISSN： 0266-8254

年卷期： 2021 年 72 卷 3 期

页码：

收录情况： SCI

摘要： Shigella spp. are water-borne pathogens responsible for mild to severe cases bacilli dysentery all around the world known as Shigellosis. The progressively increasing of antibiotic resistance among Shigella calls for developing and establishing novel alternative therapeutic methods. The present study aimed to evaluate a novel phage cocktail of lytic phages against extended spectrum beta lactamase isolates of Shigella species in an aquatic environment. The phage cocktail containing six novel Shigella specific phages showed a broad host spectrum. The cocktail was very stable in aquatic environment. The cocktail resulted in about 99% decrease in the bacterial counts in the contaminated water by several species and strains of Shigella such as Shigella sonnei, Shigella flexneri and Shigella dysenteriae. Achieving such a high efficiency in this in-vitro study demonstrates a high potential for in-vivo and in-situ application of this phage cocktail as a bio-controlling agent against Shigella spp. contamination and infections.

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