Immune duration of a recombinant PRRSV vaccine expressing E2 of CSFV

文献类型： 外文期刊

第一作者： Gao, Fei

作者： Gao, Fei;Jiang, Yifeng;Li, Guoxin;Zhang, Yujiao;Zhao, Kuan;Zhu, Haojie;Li, Liwei;Yu, Lingxue;Zheng, Hao;Zhou, Yanjun;Tong, Wu;Tong, Guangzhi;Gao, Fei;Jiang, Yifeng;Zheng, Hao;Zhou, Yanjun;Tong, Wu;Tong, Guangzhi

作者机构：

关键词： rPRRSV-E2; Duration of immunity; Lung lesion; Viral load

期刊名称：VACCINE （ 影响因子：3.641； 五年影响因子：3.816 ）

ISSN： 0264-410X

年卷期： 2020 年 38 卷 50 期

页码：

收录情况： SCI

摘要： Classical swine fever virus (CSFV) and Porcine reproductive and respiratory syndrome virus (PRRSV) are both important pathogens which seriously harm the economic swine industry worldwide. We have previously demonstrated that rPRRSV-E2 is a promising live, virus-vectored vaccine that provides 100% protection against highly pathogenic PRRSV (HP-PRRSV) and CSFV. Here, we evaluated the duration of immunity (DOI) of the vaccine strain, rPRRSV-E2. Vaccine or cell culture medium was administered to piglets at 4 weeks of age. All immunized piglets developed high levels of antibodies, which could maintain for up to 23 weeks, against PRRSV and CSFV. All immunized pigs were well protected from the challenge of HP-PRRSV or CSFV at 20 weeks and 24 weeks post vaccination. The vaccine protection rate was still 100% at 24 weeks after immunization. The immune efficacy results showed that the immune duration of rPRRSV-E2 could be up to 5 months. (C) 2020 Elsevier Ltd. All rights reserved.

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