Immunomodulation effects of polyphenols from thinned peach treated by different drying methods on RAW264.7 cells through the NF-kappa B and Nrf2 pathways

文献类型： 外文期刊

第一作者： Guo, Chongting

作者： Guo, Chongting;Bi, Jinfeng;Li, Xuan;Lyu, Jian;Liu, Xuan;Wu, Xinye;Liu, Jianing;Guo, Chongting

作者机构：

关键词： Immunomodulation; Polyphenols; Dried thinned peach; NF-kappa B; Nrf2

期刊名称：FOOD CHEMISTRY （ 影响因子：7.514； 五年影响因子：7.516 ）

ISSN： 0308-8146

年卷期： 2021 年 340 卷

页码：

收录情况： SCI

摘要： Thinned peach is abundant in polyphenols, and has been shown to exhibit various bioactivities. In this study, we evaluated the underlying immunomodulatory activity of polyphenol extracts of thinned peach (PETP) via the NF-kappa B and Nrf2 signaling pathways in RAW264.7 macrophages. The results demonstrated that the PETP efficiently activated the nuclear translocation of NF-kappa B and Nrf2, as well as downstream cytokines (IL-1 beta, IL-6, TNF alpha and IFN-gamma), SOD activity and ROS levels in RAW264.7 cells. Specifically, the PETP of natural drying and hot air drying exhibited less efficacy than that of freeze drying in NF-kappa B pathway. Interestingly, the PETP of hot air drying at 50 degrees C was more effective than freeze-dried PETP in activating Nrf2 nuclear translocation. Additionally, 50 mu g/mL PETP enhanced immune responses, whereas 800 mu g/mL PETP inhibited inflammatory development in macrophages. These findings indicated that different PETP affected the immunomodulation effects differently, which associated with the drying methods and incubation concentrations.

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